AMPA receptor trafficking and LTP: Carboxy-termini, amino-termini and TARPs
Javier Díaz-Alonso, Roger A. Nicoll
Abstract
AMPA receptors (AMPARs) are fundamental elements in excitatory synaptic transmission and synaptic plasticity in the CNS. Long term potentiation (LTP), a form of synaptic plasticity which contributes to learning and memory formation, relies on the accumulation of AMPARs at the postsynapse. This phenomenon requires the coordinated recruitment of different elements in the AMPAR complex. Based on recent research reviewed herein, we propose an updated AMPAR trafficking and LTP model which incorporates both extracellular as well as intracellular mechanisms. This article is part of the special Issue on 'Glutamate Receptors - AMPA receptors'.
Topics & Concepts
AMPA receptorLong-term potentiationSynaptic plasticityNeuroscienceMetaplasticitySynaptic scalingNeurotransmissionGlutamate receptorLong-term depressionSilent synapseExcitatory postsynaptic potentialReceptorBiologyChemistryBiochemistryInhibitory postsynaptic potentialNeuroscience and Neuropharmacology ResearchMolecular Sensors and Ion DetectionPharmacological Receptor Mechanisms and Effects