Enantioselective Hydrosilylation of β,β‐Disubstituted Enamides to Construct α‐Aminosilanes with Vicinal Stereocenters
Wenwen Zhang, Bi‐Jie Li
Abstract
Despite the advances in the area of catalytic alkene hydrosilylation, the enantioselective hydrosilylation of alkenes bearing a heteroatom substituent is scarce. Here we report a rhodium-catalyzed hydrosilylation of β,β-disubstituted enamides to directly afford valuable α-aminosilanes in a highly regio-, diastereo-, and enantioselective manner. Stereodivergent synthesis could be achieved by regulating substrate geometry and ligand configuration to generate all the possible stereoisomers in high enantio-purity.
Topics & Concepts
Enantioselective synthesisHydrosilylationStereocenterAlkeneChemistrySubstituentHeteroatomStereochemistryLigand (biochemistry)CatalysisOrganic chemistryRing (chemistry)BiochemistryReceptorAsymmetric Hydrogenation and CatalysisOrganoboron and organosilicon chemistryCatalytic C–H Functionalization Methods