Conjugation Inhibitors Effectively Prevent Plasmid Transmission in Natural Environments
Carolina Palencia-Gándara, María Getino, Gabriel Moyano, Santiago Redondo, Raúl Fernández-López, Bruno González‐Zorn, Fernando de la Cruz
Abstract
. Here we show that COINS efficiently block plasmid transmission in two controlled natural environments, water microcosms and the mouse gut. These observations indicate that COIN therapy can be used to prevent the spread of antibiotic resistance.
Topics & Concepts
PlasmidAntibioticsBacteriaAntibiotic resistanceIn vivoMicrobiologyBacterial conjugationBiologyPathogenic bacteriaGeneIn vitroChemistryBiochemistryBiotechnologyGeneticsPharmaceutical and Antibiotic Environmental ImpactsAntibiotic Resistance in BacteriaBacteriophages and microbial interactions