CRISPR-Cas12a delivery by DNA-mediated bioresponsive editing for cholesterol regulation
Wujin Sun, Jinqiang Wang, Quanyin Hu, Xingwu Zhou, Ali Khademhosseini, Zhen Gu
Abstract
disruption was observed in vivo (~48%), significantly reducing the expression of PCSK9 and gaining the therapeutic benefit of cholesterol control (~45% of cholesterol reduction).
Topics & Concepts
CRISPRDNAGenome editingComputational biologyTrans-activating crRNAChemistryBiologyGeneticsGeneCRISPR and Genetic EngineeringInnovation and Socioeconomic DevelopmentMosquito-borne diseases and control