Synthesis, Intramolecular Cyclization, and Anti-inflammatory Activity of Substituted 2-[2-(4-R-Benzoyl)hydrazinylidene]-4-oxobutanoic Acids
D. V. Lipin, E. I. Denisova, D. A. Shipilovskikh, Р. Р. Махмудов, Н. М. Игидов, Sergei A. Shipilovskikh
Abstract
Abstract The substrate scope of the procedure for the synthesis of 2-[2-(4-R-benzoyl)hydrazinylidene]-4-oxobutanoic acids was expanded, and their intramolecular cyclization in the presence of propionic anhydride was studied. The synthesized compounds were evaluated for their anti-inflammatory activity and acute toxicity. Some compounds showed a significant anti-inflammatory activity at a level comparable to or exceeding that for medically used reference drugs.
Topics & Concepts
ChemistryIntramolecular forceSubstrate (aquarium)Combinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryGeologyOceanographyChemical synthesis and pharmacological studiesSynthesis and Reactions of Organic CompoundsSynthesis of heterocyclic compounds