Enantioselective and regioselective aza-Friedel–Crafts reaction of electron-rich phenols with isatin-derived ketimines
Liu Cai, Xiang-Shuai Liu, Jie Wang, Li Chen, Xin Li, Jin‐Pei Cheng
Abstract
/CPA system, gave a series of chiral 3-amino-2-oxindoles with high yields (up to 99%), excellent enantioselectivities (up to 99%) and moderate to very good regioselectivities (up to 25/1).
Topics & Concepts
RegioselectivityIsatinFriedel–Crafts reactionPhenolsChemistryEnantioselective synthesisOrganic chemistryMedicinal chemistryCatalysisAsymmetric Synthesis and CatalysisSynthesis and Catalytic ReactionsChemical Synthesis and Reactions