Free‐Radical‐Promoted Alkenylation of C(<i>sp</i><sup>3</sup>)−H Bond in Chloroalkane with Cinnamic Acid and <i>β</i>‐Nitrostyrene
Minzhi Sun, Zhengbao Xu, Wenjie Li, Le Yang, Huichao You, Dan Yu, Fang Fang, Yaxin Wang, Zhong‐Quan Liu
Abstract
Abstract We demonstrated herein a free‐radical alkenylation of the C( sp 3 )−H bond in 1,2‐dichloroethane with cinnamic acid and β ‐nitrostyrene. This method not only provides a facile approach to chloroalkylated styrenes, but also would be instructive for halogen‐atom directing selective functionalization of inert C( sp 3 )−H bond. magnified image
Topics & Concepts
ChemistryCinnamic acidDouble bondHalogenFree-radical additionMedicinal chemistryPolymer chemistryStereochemistryOrganic chemistryAlkylCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsOxidative Organic Chemistry Reactions