SRC-3, a Steroid Receptor Coactivator: Implication in Cancer
Licen Li, Chu‐Xia Deng, Qiang Chen
Abstract
Steroid receptor coactivator-3 (SRC-3), also known as amplified in breast cancer 1 (AIB1), is a member of the SRC family. SRC-3 regulates not only the transcriptional activity of nuclear receptors but also many other transcription factors. Besides the essential role of SRC-3 in physiological functions, it also acts as an oncogene to promote multiple aspects of cancer. This review updates the important progress of SRC-3 in carcinogenesis and summarizes its mode of action, which provides clues for cancer therapy.
Topics & Concepts
Nuclear receptor coactivator 3CoactivatorProto-oncogene tyrosine-protein kinase SrcNuclear receptor coactivator 2Nuclear receptorNuclear receptor coactivator 1Cancer researchCarcinogenesisBreast cancerReceptorOncogeneCancerTranscription factorBiologyBioinformaticsGeneticsGeneCell cycleEstrogen and related hormone effectsComputational Drug Discovery MethodsCytokine Signaling Pathways and Interactions