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GLP-1R knockdown abrogates the protective effects of liraglutide on ischaemic stroke via inhibition of M2 polarisation and activation of NLRP3 inflammasome by reducing Nrf2 activation

Xian-kun Tu, Pingping Chen, Jingyi Chen, Yi-hang Ding, Quan Chen, Song‐sheng Shi

2023Neuropharmacology10 citationsDOI

Topics & Concepts

LiraglutideGene knockdownNeuroprotectionMedicinePharmacologyTUNEL assayEndocrinologyApoptosisInternal medicineChemistryDiabetes mellitusBiochemistryType 2 diabetesImmunohistochemistryNeuroinflammation and Neurodegeneration MechanismsMicroRNA in disease regulationNeurological Disease Mechanisms and Treatments
GLP-1R knockdown abrogates the protective effects of liraglutide on ischaemic stroke via inhibition of M2 polarisation and activation of NLRP3 inflammasome by reducing Nrf2 activation | Litcius