Resveratrol alleviates bleomycin-induced pulmonary fibrosis by inhibiting epithelial-mesenchymal transition and down-regulating TLR4/NF-κB and TGF-β1/smad3 signalling pathways in rats
Lei Wang, Mei Shao, Wei Jiang, Yangfeng Huang
Topics & Concepts
Epithelial–mesenchymal transitionBleomycinPulmonary fibrosisResveratrolVimentinFibrosisTLR4Signal transductionCancer researchNF-κBOxidative stressChemistryDownregulation and upregulationIdiopathic pulmonary fibrosisLungInflammationMedicinePharmacologyImmunologyPathologyInternal medicineImmunohistochemistryBiochemistryGeneChemotherapyInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisSirtuins and Resveratrol in MedicineIon Channels and Receptors