Structural characterization and preventive effect on non-alcoholic fatty liver disease of oligosaccharides from <i>Bletilla striata</i>
Baifei Hu, Huabing Yang, Guangming Chen, Xiongjie Sun, Xiaojuan Zou, Jun Ma, Xiaowei Yao, Qiong Liang, Hongtao Liu
Abstract
oligosaccharides (BOs) were composed of mannose and glucose with a molar ratio of 5.2 : 1, and the main backbones of BOs contained (1→4)-linked-α-D-Man, (1→2)-linked-α-D-Man, and (1→2)-linked-α-D-Glc. By using a high-fat diet (HFD)-induced mouse model, we demonstrated that BOs had an improving effect on non-alcoholic fatty liver disease (NAFLD). Using the metabolomics assay, we found that BOs significantly regulated the hepatic metabolism of fatty acids, arachidonic acid, and other related metabolites in HFD-fed mice, accompanied by the reduction of lipid accumulation and fibrosis in liver tissues. In summary, BOs displayed high potential for the treatment of NAFLD as a functional food.