Enantioselective Ni‐Catalyzed Three‐Component Dicarbofunctionalization of Alkenes
Zhan Dong, Liangliang Song, Liang‐An Chen
Abstract
Abstract Asymmetric multicomponent reactions are considered as efficient protocols for constructing complex chiral molecules because of their step‐ and atom‐economy. Nickel‐catalyzed asymmetric three‐component dicarbofunctionalization of alkenes has been well developed in recent years, which is used in the area of total synthesis of natural products and late‐stage modification of drugs because of the rapid incorporation of chiral sp 3 ‐enriched carbon centers. In this concept, the significant breakthroughs of this field are summarized, together with the related mechanisms. Moreover, the remaining challenges and potential opportunities of multicomponent dicarbofunctionalization are also highlighted.
Topics & Concepts
Enantioselective synthesisCatalysisAtom economyComponent (thermodynamics)Combinatorial chemistryAsymmetric carbonNickelChemistryCarbon fibersCarbon atomMoleculeOrganic chemistryMaterials scienceOptically activePhysicsAlkylComposite numberComposite materialThermodynamicsCatalytic C–H Functionalization MethodsAsymmetric Synthesis and CatalysisCyclopropane Reaction Mechanisms