The moonlighting protein c-Fos activates lipid synthesis in neurons, an activity that is critical for cellular differentiation and cortical development
Lucía Rodriguez-Berdini, Gabriel O. Ferrero, Florentyna Bustos Plonka, Andrés M. Cardozo Gizzi, César G. Prucca, Santiago Quiroga, Beatriz L. Caputto
Abstract
electroporation model, we observed that neurons with blocked c-Fos expression or lacking its AP-1-independent activity fail to initiate cortical development. These results highlight the importance of c-Fos-mediated activation of lipid synthesis for proper nervous system development.
Topics & Concepts
Cell biologyLipid accumulationChemistryCortical neuronsNeuroscienceBiologyBiochemistryMitochondrial Function and PathologyATP Synthase and ATPases ResearchEndoplasmic Reticulum Stress and Disease