The role of metabolites of steviol glycosides and their glucosylated derivatives against diabetes-related metabolic disorders
Yuqi Li, Wanfang Zhu, Jing Cai, Wenyuan Liu, Toshihiro Akihisa, Wei Li, Takashi Kikuchi, Jian Xu, Feng Feng, Jie Zhang
Abstract
leaf, while GSGs are mainly manufactured using enzymes that transfer glucose units from a starch source to SGs. Results from this study suggest that SGs and GSGs share same bioactive metabolites, steviol and steviol glucuronide (SVG), which exhibit anti-hyperglycemic effects by activating glucose-induced insulin secretion to enhance pancreatic β-cell function. In addition, steviol and SVG have been found to ameliorate the inflammatory response, lipid imbalance, myocardial fibrosis and renal functions to modulate diabetes-related metabolic disorders. Therefore, both SGs and GSGs may be used as potential sucrose alternatives and/or pharmacological alternatives for preventing and treating metabolic disorders.