Pan-caspase inhibition as a potential host-directed immunotherapy against MRSA and other bacterial skin infections
Martin P. Alphonse, Jessica Rubens, Roger V. Ortines, Nicholas Orlando, Aman M. Patel, Dustin Dikeman, Yu Wang, Ivan Vuong, Daniel Joyce, Jeffrey Zhang, Mohammed Mumtaz, Haiyun Liu, Qi Liu, Christine Youn, Garrett J. Patrick, Advaitaa Ravipati, Robert J. Miller, Nathan K. Archer, Lloyd Miller
Abstract
skin infections in mice. Collectively, pan-caspase inhibition represents a potential host-directed immunotherapy against MRSA and other bacterial skin infections.
Topics & Concepts
NecroptosisInflammasomeCaspase 1PyroptosisApoptosisTumor necrosis factor alphaMicrobiologyCaspase 3Caspase 8CaspaseImmunologyStaphylococcus aureusBiologyInflammationProgrammed cell deathBiochemistryBacteriaGeneticsInflammasome and immune disordersStreptococcal Infections and TreatmentsCell death mechanisms and regulation