Loss of DDRGK1 impairs IRE1α UFMylation in spondyloepiphyseal dysplasia
Xiao Yang, Tangjun Zhou, Xin Wang, Ying Xia, Xiankun Cao, Xiaofei Cheng, Yu Cao, Peixiang Ma, Hui Ma, An Qin, Jie Zhao
Abstract
In conclusion, DDRGK1 stabilizes IRE1α to ameliorate ER stress and following apoptosis in chondrocytes, which finally promote the normal chondrogenesis.
Topics & Concepts
Endoplasmic reticulumUnfolded protein responseCell biologyMutantChondrogenesisBiologyProteasomeApoptosisMutationChemistryGeneticsGeneStem cellEndoplasmic Reticulum Stress and DiseaseUbiquitin and proteasome pathwaysAutophagy in Disease and Therapy