Schisandrin C attenuates renal damage in diabetic nephropathy by regulating macrophage polarization.
Yu Wang, Jingqiu Cui, Ming Liu, Yingqi Shao, Xiaoying Dong
Abstract
cells, IL-10 and TGF-β expression increased following Schisandrin-C-treatment. Finally, Schisandrin C inhibited the expression of Swiprosin-1, IFN-γ-Rβ, phospho-Janus kinase 2 (p-JAK2), phospho-signal transducer and activator of transcription 1 (p-STAT1), and p-STAT3, in both DN model mice and high-glucose-stimulated RAW264.7 cells. The present study indicated a novel use for Schisandrin C to suppress DN progression, by promoting M1 to M2 macrophage polarization. Schisandrin C exerted protective effects against DN by regulating the polarization-dependent Swiprosin-1/IFN-γ-Rβ signaling pathway in macrophages.
Topics & Concepts
InterleukinPharmacologyTumor necrosis factor alphaDiabetic nephropathyMedicineSTAT proteinMacrophage polarizationChemistrySTAT3EndocrinologyApoptosisInternal medicineCytokineKidneyMacrophageIn vitroBiochemistryPlant-derived Lignans Synthesis and BioactivityGenomics, phytochemicals, and oxidative stressSphingolipid Metabolism and Signaling