Design, synthesis, and bioimaging applications of a new class of carborhodamines
Xin Lv, Taihe Han, Xia Yuan, Hu Shi, Wei Guo
Abstract
We herein developed a new class of carborhodamines (CRs), i.e. 10-methoxy-substituted carborhodamines MCRs, by a simple synthesis procedure, which have absorption and emission wavelengths longer than classical CRs while retaining their excellent photophysical properties. Based on the MCR platform, we constructed the mitochondria-targeted fluorescent probe MCR-DMA and demonstrated its potential for sensing singlet oxygen (1O2) in living cells during the photodynamic therapy process.
Topics & Concepts
Class (philosophy)FluorescenceChemistryNanotechnologySimple (philosophy)Computer scienceCombinatorial chemistryAnalytical Chemistry (journal)Materials sciencePhysicsChromatographyOpticsArtificial intelligenceEpistemologyPhilosophyMolecular Sensors and Ion DetectionLuminescence and Fluorescent MaterialsNanoplatforms for cancer theranostics