Efficient Inhibition of Hepatitis B Virus (HBV) Replication and cccDNA Formation by HBV Ribonuclease H Inhibitors during Infection
Ranjit Chauhan, Qilan Li, Molly E. Woodson, Makafui Gasonoo, Marvin J. Meyers, John E. Tavis
Abstract
s against replication of wild-type, lamivudine-resistant, and adefovir/lamivudine-resistant HBV, as expected because the RNase H inhibitors do not target the viral reverse transcriptase active site. These studies expand confidence in inhibiting the HBV RNase H as a drug strategy and support inclusion of RNase H inhibitors in novel curative drug combinations for HBV.
Topics & Concepts
cccDNAHepatitis B virusVirologyBiologyCytotoxicityViral replicationRNase PRibonucleaseReverse transcriptaseRNase HCell cultureMolecular biologyHBsAgTransfectionCytotoxic T cellHepadnaviridaeIntracellularVirusHepatitis BEnzymeChemistryHBeAgHepatitis B Virus StudiesHeat shock proteins researchHIV/AIDS drug development and treatment