Extracellular-vesicle containing miRNA-503-5p released by macrophages contributes to atherosclerosis
Yuquan Wang, Zhengmin Xu, Xiaoli Wang, Jiankang Zheng, Lihan Peng, Yunfei Zhou, Yongyan Song, Zhan Lu
Abstract
the down-regulation of smad family members 1, 2 and 7. The inhibition of miR-503-5p by lentivirus reduced atherosclerotic lesion formations in the aorta of atherosclerotic mice. Our work demonstrated a miR-503-5p- and EV-mediated mechanism for macrophage communication with HCAECs and HCASMCs in atherosclerosis. miR-503-5p is pro-atherosclerotic stimuli that may be a therapeutic target for atherosclerosis treatment.
Topics & Concepts
Extracellular vesiclesExtracellular vesicleExtracellularmicroRNACell biologyChemistryMicrovesiclesMacrophageBiologyBiochemistryGeneIn vitroExtracellular vesicles in diseaseMicroRNA in disease regulationCardiovascular Disease and Adiposity