miR-196a provides antioxidative neuroprotection via USP15/Nrf2 regulation in Huntington's disease
Siew Chin Chan, Chih‐Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei‐Hsun Cheng, Chuan‐Mu Chen, Shang‐Hsun Yang
Topics & Concepts
NeuroprotectionHuntingtinNeurodegenerationKEAP1Oxidative stressHuntington's diseaseCell biologyBiologyReactive oxygen speciesTranscription factorProgrammed cell deathPharmacologyChemistryBiochemistryMutantApoptosisDiseaseInternal medicineGeneMedicineGenetic Neurodegenerative DiseasesMitochondrial Function and PathologyMuscle Physiology and Disorders