Mitoxantrone impairs proteasome activity and prompts early energetic and proteomic changes in HL-1 cardiomyocytes at clinically relevant concentrations
Vera Marisa Costa, João Paulo Capela, Joana R. Sousa, Rute P. Eleutério, Patrícia Rodrigues, José Luís Dores‐Sousa, Rui A. Carvalho, Maria de Lourdes Bastos, José Alberto Duarte, Fernando Remião, M. Gabriela Almeida, Kurt J. Varner, Félix Carvalho
Topics & Concepts
Lactate dehydrogenaseMitoxantroneCardiotoxicityCytotoxicityGlutathioneChemistryIntracellularPharmacologyIncubationToxicityInternal medicineBiochemistryMedicineEnzymeChemotherapyIn vitroChemotherapy-induced cardiotoxicity and mitigationCancer Treatment and PharmacologySynthesis and Biological Evaluation