Transcription and DNA replication collisions lead to large tandem duplications and expose targetable therapeutic vulnerabilities in cancer
Yang Yang, Michelle L. Badura, Patrick C. O’Leary, Henry M. Delavan, Troy M. Robinson, Emily A. Egusa, Xiaoming Zhong, Jason Swinderman, Haolong Li, Meng Zhang, Minkyu Kim, Alan Ashworth, Felix Y. Feng, Jonathan Chou, Lixing Yang
Topics & Concepts
BiologyTranscription (linguistics)DNA damageGenome instabilityDNA replicationCancer researchSomatic cellGenomeProstate cancerMicrosatellite instabilityGeneGeneticsTandem repeatDNACancerMicrosatelliteLinguisticsAllelePhilosophyCancer Genomics and DiagnosticsDNA Repair MechanismsBRCA gene mutations in cancer