Paired box 6 programs essential exocytotic genes in the regulation of glucose-stimulated insulin secretion and glucose homeostasis
Wing Yan So, Wai Nam Liu, Adrian Kee Keong Teo, Guy A. Rutter, Weiping Han
Abstract
PAX6 replenishment improves glucose-stimulated insulin secretion and glucose homeostasis in diabetic mice and primary human islets.
Topics & Concepts
PAX6EndocrinologyInternal medicineGlucose homeostasisBeta cellPancreatic isletsBiologyInsulinIsletCREBInsulin resistanceTranscription factorMedicineGeneGeneticsPancreatic function and diabetesGenetics and Neurodevelopmental DisordersDiabetes and associated disorders