Stepwise Evolution of a Klebsiella pneumoniae Clone within a Host Leading to Increased Multidrug Resistance
Mai Yoshino, Masamune Aihara, Yasuhiro Gotoh, Masaru Akimoto, Wakana Tatsuhara, Makiko Kiyosuke, Yuichi Matsushima, Takeshi Uchiumi, Tetsuya Hayashi, Dongchon Kang
Abstract
Within-host evolution is a survival strategy that can occur in many pathogens and is often associated with the emergence of novel antimicrobial-resistant (AMR) bacteria. To analyze this process, suitable sets of clinical isolates are required.
Topics & Concepts
BiologyKlebsiella pneumoniaeclone (Java method)Multiple drug resistanceGeneMicrobiologyGeneticsGenomeBacteriaColistinMyeloid leukemiaMutationComplementationPlasmidDrug resistanceWhole genome sequencingBacterial geneticsSubtypingVirologyMutantHost (biology)Antibiotic resistanceEnterobacteriaceaeAntibiotic Resistance in BacteriaEvolution and Genetic DynamicsEscherichia coli research studies