KLF2 enhancer variant rs4808485 increases lupus risk by modulating inflammasome machinery and cellular homoeostasis
Manish Kumar Singh, Harikrishna Reddy Rallabandi, Shu‐Feng Zhou, Yuanyuan Qi, Zhanzheng Zhao, Ting Gan, Hong Zhang, Loren L. Looger, Swapan K. Nath
Topics & Concepts
CTCFH3K4me3KLF2EpigeneticsBiologyGenome-wide association studyEnhancerTXNIPChromatin immunoprecipitationChromatinJurkat cellsExpression quantitative trait lociInflammasomeGeneticsEpigenomicsRegulation of gene expressionGene knockdownTranscription factorGene expressionDNA methylationGenePromoterSingle-nucleotide polymorphismT cellGenotypeThioredoxinImmune systemReceptorKruppel-like factors researchLipid metabolism and disordersGenetic Syndromes and Imprinting