Mitochondrial Control in Inflammatory Gastrointestinal Diseases
Guo-Yan Sui, Feng Wang, Jin Lee, Yoon Seok Roh
Abstract
Mitochondria play a central role in the pathophysiology of inflammatory bowel disease (IBD) and colorectal cancer (CRC). The maintenance of mitochondrial function is necessary for a stable immune system. Mitochondrial dysfunction in the gastrointestinal system leads to the excessive activation of multiple inflammatory signaling pathways, leading to IBD and increased severity of CRC. In this review, we focus on the mitochondria and inflammatory signaling pathways and its related gastrointestinal diseases.
Topics & Concepts
Inflammatory bowel diseaseMitochondrionImmune systemInflammationColorectal cancerPathophysiologySignal transductionInflammatory Bowel DiseasesMedicineDiseaseImmunologyBioinformaticsBiologyCancerCancer researchInternal medicineCell biologyImmune cells in cancerInflammasome and immune disordersTuberculosis Research and Epidemiology