Synthesis and biological evaluation of novel bis-quaternary ammonium compounds with p-terphenyl spacer
A. N. Vereshchagin, Nikita A. Frolov, Valeria Yu. Konyuhova, Evgeniya O. Dorofeeva, Karl A. Hansford, Mikhail P. Egorov
Abstract
Novel bis-quaternary ammonium compounds with a p-terphenyl spacer between two pyridinium heads were synthesized. Hit compound with C8H17 aliphatic substituent is superior to known benzalkonium chloride, miramistin and chlorhexidine bisgluconate in MIC values against five pathogenic bacteria.
Topics & Concepts
ChemistryTerphenylPyridiniumBenzalkonium chlorideAmmoniumChlorhexidineSubstituentAmmonium chlorideChlorideOrganic chemistryMedicinal chemistryDentistryMedicineAntimicrobial agents and applicationsPhenothiazines and Benzothiazines Synthesis and ActivitiesMulticomponent Synthesis of Heterocycles