Ligand-Free Iron-Catalyzed Construction of C–P Bonds via Phosphorylation of Alcohols: Synthesis of Phosphine Oxides and Phosphine Compounds
Liguang Gan, Changxu Ye, T.-W. Pi, Lingling Wang, Chunya Li, Long Liu, Tianzeng Huang, Tieqiao Chen, Li‐Biao Han
Abstract
An efficient method for the construction of C-P(V) and C-P(III) bonds via the iron-catalyzed phosphorylation of alcohols under ligand-free conditions is disclosed. This strategy represents a straightforward process to prepare a series of phosphine oxides and phosphine compounds in good to excellent yields from the readily available alcohols and P-H compounds. A plausible mechanism is also proposed. We anticipate that this mode of transforming simple alcohols would apply in chemical synthesis widely.
Topics & Concepts
PhosphineLigand (biochemistry)ChemistryCatalysisCombinatorial chemistryOrganic chemistryReceptorBiochemistryAsymmetric Hydrogenation and CatalysisOrganophosphorus compounds synthesisChemical Synthesis and Analysis