RdxA Diversity and Mutations Associated with Metronidazole Resistance of <i>Helicobacter pylori</i>
Yanan Gong, Kangle Zhai, Lu Sun, Lihua He, Hairui Wang, Yahui Guo, Jianzhong Zhang
Abstract
The increasing resistance to metronidazole impaired the efficacy of Helicobacter pylori eradication, and increasing the dose of metronidazole was recommended to overcome low-level resistance. For patients infected with highly resistant strains, the current empirical treatments, which generally used metronidazole in double doses or more, appeared impossibly to overcome the resistance and would only increase the incidence of adverse effects.
Topics & Concepts
Missense mutationBiologyMutationHelicobacter pyloriGeneticsFrameshift mutationAntibiotic resistancePhenotypeNonsense mutationMetronidazoleGeneMicrobiologyBacteriaAntibioticsHelicobacter pylori-related gastroenterology studiesClostridium difficile and Clostridium perfringens researchAntimicrobial Resistance in Staphylococcus