STING differentially regulates experimental GVHD mediated by CD8 versus CD4 T cell subsets
Cameron S. Bader, Henry Barreras, Casey O. Lightbourn, Sabrina Copsel, Dietlinde Wolf, Jingjing Meng, Jeonghyun Ahn, Krishna V. Komanduri, Bruce R. Blazar, Lei Jin, Glen N. Barber, Sabita Roy, Robert B. Levy
Abstract
T cells in completely mismatched recipients. In total, our findings have important implications for regulating clinical GVHD by targeting STING early after aHSCT and demonstrate that an innate immune pathway has opposing effects on the outcome of aHSCT, depending on the donor/recipient MHC disparity.
Topics & Concepts
StingCD8T cellImmunologyGraft-versus-host diseaseCytotoxic T cellBiologyDiseaseCell biologyCellMedicineCancer researchImmune systemGeneticsInternal medicineStem cellAerospace engineeringEngineeringIn vitrointerferon and immune responsesViral Infections and VectorsViral Infections and Outbreaks Research