A Facile Synthesis of Self-Catalytic Hydrogel Films and Their Application as a Wound Dressing Material Coupled with Natural Active Compounds
Supachai Thongsuksaengcharoen, Siritron Samosorn, Kriangsak Songsrirote
Abstract
. Additionally, the anti-inflammatory study revealed that 700 μg/mL berberine and 2500 μg/mL chlorogenic acid could inhibit protein degradation equivalent to a 200 μg/mL aspirin solution. The drug release study demonstrated that both compounds showed a more sustained release into PBS than water. The mechanism for the three-dimensional network formation based on esterification and the hydrogen-bonding interaction was also proposed. The ionic liquid-like structure of PVP-CA possibly played an important role in the cross-linking process. In addition, sodium bicarbonate applied to the synthesized hydrogel also had a significant effect in enhancing gel formation. The proposed approach showed a potential of the loaded hydrogels to protect wounds from infection and enhance the healing process.