Emulating the chondrocyte microenvironment using multi-directional mechanical stimulation in a cartilage-on-chip
Carlo Alberto Paggi, Jan Hendriks, Marcel Karperien, Séverine Le Gac
Abstract
The multi-directional mechanical stimulation experienced by cartilage during motion is transferred to chondrocytes, which respond by releasing matrix proteins and/or matrix-degrading enzymes.
Topics & Concepts
ChondrocyteCartilageExtracellular matrixAggrecanStimulationHyaline cartilageChemistryMatrix (chemical analysis)Biomedical engineeringCell biologyChondrogenesisGlycosaminoglycanMaterials scienceAnatomyBiophysicsPathologyOsteoarthritisBiologyMedicineNeuroscienceBiochemistryArticular cartilageAlternative medicineChromatographyOsteoarthritis Treatment and MechanismsKnee injuries and reconstruction techniquesTendon Structure and Treatment