<i>p</i>-Synephrine ameliorates alloxan-induced diabetes mellitus through inhibiting oxidative stress and inflammation <i>via</i> suppressing the NF-kappa B and MAPK pathways
Yali Wang, Song‐Xia Lin, Yuan Wang, Tao Liang, Tao Jiang, Peng Liu, Xiaoyi Li, Deng-Qin Lang, Qiang Liu, Chunyan Shen
Abstract
p -Synephrine has been popularly used as a dietary supplement for weight loss. This study showed that p -synephrine treatment prevented diabetes mellitus by inhibiting oxidative stress and inflammation via suppressing the NF-kappa B and MAPK pathways.
Topics & Concepts
Oxidative stressEndocrinologyInternal medicineChemistryAlloxanMalondialdehydeInflammationDiabetes mellitusSuperoxide dismutaseGlutathionePharmacologyAntioxidantMedicineBiochemistryEnzymeNatural Antidiabetic Agents StudiesPhytochemicals and Antioxidant ActivitiesAdipokines, Inflammation, and Metabolic Diseases