The cGAS-STING pathway: a therapeutic target in chromosomally unstable cancers
Haiyan Yan, Weiguo Lü, Fangwei Wang
Abstract
In a recent study published in Nature , Hong et al. revealed that the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) innate immune pathway is critically required for the IL-6-dependent survival of chromosomally unstable cancer cells, 1 implying that chronic inflammation can be therapeutically targeted to kill cancers displaying chromosomal instability (CIN).
Topics & Concepts
StingCancer researchBiologyMedicineImmunologyComputational biologyPhysicsThermodynamicsinterferon and immune responsesUbiquitin and proteasome pathwaysViral Infections and Vectors