Control of Axial Chirality through NiH-Catalyzed Atroposelective Hydrofunctionalization of Alkynes
Feng‐Tao Sheng, Shi‐Chao Wang, Junqian Zhou, Changpeng Chen, You Wang, Shaolin Zhu
Abstract
Catalytic asymmetric hydrofunctionalization of alkenes is a well-established method with which to construct complex C(sp 3 )-enriched molecules with central chirality. In contrast, the use of catalytic asymmetric hydrofunctionalization of abundant alkyne substrates to produce valuable multisubstituted alkenes with axial chirality remains largely unexplored. Here, we report a general procedure of this type catalyzed by abundant Ni(II) salts and employing a structurally simple chiral PyrOx ligand. A wide variety of structurally diverse atropisomeric chiral styrenes have been obtained from hydroarylation of alkynes with high efficiency, complete Z -selectivity, and excellent enantioselectivity.