Spontaneous Formation of 3D Breast Cancer Tissues on Electrospun Chitosan/Poly(ethylene oxide) Nanofibrous Scaffolds
Amna M. I. Rabie, Ahmed S. M. Ali, Munir A. Al‐Zeer, Ahmed Barhoum, Salwa M. El‐Hallouty, Wafaa Gh. Shousha, Johanna Berg, Jens Kurreck, Ahmed S.G. Khalil
Abstract
extracellular matrix in the tumor microenvironment. Detailed mechanisms for the spontaneous formation of the 3D microtissues have been proposed. Our results suggest that scaffold surface topography significantly influences tissue formation and behavior of the cells.
Topics & Concepts
ElectrospinningChitosanScaffoldSpheroidCell cultureMaterials scienceEthylene oxideTissue engineeringMTT assayNanofiberBiomedical engineeringTissue cultureBiophysicsChemistryCell growthNanotechnologyIn vitroPolymerComposite materialBiochemistryMedicineBiologyGeneticsCopolymerElectrospun Nanofibers in Biomedical Applications3D Printing in Biomedical ResearchTissue Engineering and Regenerative Medicine