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Identification of a promising hit from a new series of pyrazolo[1,5-a]pyrimidine based compounds as a potential anticancer agent with potent CDK1 inhibitory and pro-apoptotic properties through a multistep in vitro assessment

Hossam R. Elgiushy, Sameh H. Mohamed, Heba Taha, Hussein Sawaf, Zeinab Hassan, Nageh A. Abou-Taleb, Eman M. El‐labbad, Ashraf S. Hassan, Khaled A. M. Abouzid, Sherif Hammad

2022Bioorganic Chemistry20 citationsDOI

Topics & Concepts

ChemistryApoptosisCyclin-dependent kinase 1Cell cycleCyclin B1Cyclin ACaspaseCell cultureMolecular biologyMTT assayKinasePolo-like kinaseCell cycle checkpointCyclin-dependent kinaseBiochemistryProgrammed cell deathBiologyGeneticsCancer Mechanisms and TherapyCancer therapeutics and mechanismsCancer-related Molecular Pathways
Identification of a promising hit from a new series of pyrazolo[1,5-a]pyrimidine based compounds as a potential anticancer agent with potent CDK1 inhibitory and pro-apoptotic properties through a multistep in vitro assessment | Litcius