PROTAC based STING degrader attenuates acute colitis by inhibiting macrophage M1 polarization and intestinal epithelial cells pyroptosis mediated by STING-NLRP3 axis

Shuai Xu, Yifeng Peng, Kai Yang, Sheng Liu, Zhanke He, Junli Huang, Ruipei Xiao, Jin Liu, Ziyan Yan, Zhiying Lian, Huayang Pan, Jianjun Chen, Jiaolong Shi, Xingxing Yao, Haijun Deng