Photoinduced Aromatization-Driven Deconstructive Fluorosulfonylation of Spiro Dihydroquinazolinones
Wenpeng Yang, Hong-Jie Miao, Gang Wang, Xiaoyu Yang, Xianjun Wang, Le Liu, Xin‐Hua Duan, Li‐Na Guo
Abstract
A catalyst-free photoinduced deconstructive fluorosulfonylation cascade of spiro dihydroquinazolinones with DABSO and NFSI is reported. This protocol features mild reaction conditions, good yields and excellent functional group tolerance, providing a practical approach to the quinazolin-4(1 H )-one-functionalized aliphatic sulfonyl fluorides. In addition, the ease of gram-scale synthesis and the versatility of the SuFEx exchange highlight the application potential of this protocol.
Topics & Concepts
AromatizationCatalysisFunctional groupSulfonylChemistryCombinatorial chemistryProtocol (science)CascadeOrganic chemistryMedicineAlkylChromatographyAlternative medicinePathologyPolymerQuinazolinone synthesis and applicationsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods