Exosomes derived from CD271<sup>+</sup>CD56<sup>+</sup> bone marrow mesenchymal stem cell subpopoulation identified by single-cell RNA sequencing promote axon regeneration after spinal cord injury
Yi Sun, Quanbo Liu, Yiming Qin, Yan Xu, Jinyun Zhao, Yong Xie, Chengjun Li, Tian Qin, Yuxin Jin, Liyuan Jiang, Yong Cao, Hongbin Lü, Jianzhong Hu
Abstract
BMSC-Exos hydrogel presents a promising and effective therapeutic approach for SCI.
Topics & Concepts
Regeneration (biology)AxonMicrovesiclesSpinal cordSpinal cord injuryMesenchymal stem cellCell biologyExosomeStem cellBone marrowNeuriteNeuroscienceBiologyChemistrymicroRNAImmunologyIn vitroGeneBiochemistryExtracellular vesicles in diseaseMicroRNA in disease regulationRNA Interference and Gene Delivery