Pathogen-driven CRISPR screens identify TREX1 as a regulator of DNA self-sensing during influenza virus infection
Cason R. King, Yiping Liu, Katherine A. Amato, Grace A. Schaack, Clayton K. Mickelson, Autumn E. Sanders, Tony Hu, Srishti Gupta, Ryan A. Langlois, Judith A. Smith, Andrew Mehle
Topics & Concepts
BiologyInnate immune systemCas9DNAVirusExonucleaseCRISPRPathogenInfluenza A virusVirologyGeneDNA virusGenomeCell biologyGeneticsImmune systemDNA polymeraseinterferon and immune responsesCRISPR and Genetic EngineeringMosquito-borne diseases and control