Photoredox/nickel dual-catalyzed regioselective alkylation of propargylic carbonates for trisubstituted allenes
Zhao‐Zhao Zhou, Xian‐Rong Song, Sha Du, Ke-Jian Xia, Wan‐Fa Tian, Qiang Xiao, Yong‐Min Liang
Abstract
a photoredox/nickel dual-catalyzed process, which represents the first direct approach to access alkylated allene products without alkyl organometallic reagents. This method features a broad substrate scope and mild conditions. A hypothetical mechanism with an alkyl radical and an allenyl Ni(III) species is proposed. Benzylation products were also obtained to be the complement building blocks for the potential synthesis of pharmaceuticals.
Topics & Concepts
RegioselectivityChemistryAlkylationReagentAlkylAlleneCombinatorial chemistryCatalysisNickelDihydropyridineOrganic chemistryCalciumCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesRadical Photochemical Reactions