Simultaneous improvement of physical stability, dissolution, bioavailability, and antithrombus efficacy of Aspirin and Ligustrazine through cocrystallization
Kairu Wang, Yanshuang Hao, Chenguang Wang, Xinghua Zhao, Xin He, Changquan Calvin Sun
Topics & Concepts
CocrystalTetramethylpyrazineBioavailabilityDrugChemistryAspirinSublimation (psychology)PharmacologyDissolutionCombinatorial chemistryOrganic chemistryMedicineMoleculeHydrogen bondBiochemistryPsychologyPathologyAlternative medicinePsychotherapistCrystallography and molecular interactionsCrystal structures of chemical compoundsCrystallization and Solubility Studies