Stereoselective Synthesis of Enantiopure Oxazolidinones via Biocatalytic Asymmetric Aminohydroxylation of Alkenes
Xiaoying Zhou, Nan‐Wei Wan, Yingna Li, Ran Ma, Bao‐Dong Cui, Wen‐Yong Han, Yong‐Zheng Chen
Abstract
Abstract Chiral oxazolidinones are of significance in both medicinal and synthetic chemistry, while preparing these compounds usually involves using expensive starting materials and harsh reaction conditions. Herein, a one‐pot biocatalytic cascade process was developed for stereo‐ and regioselective aminohydroxylation of diverse alkenes by combining styrene monooxygenase and halohydrin dehalogenase, providing an approach to enantiopure oxazolidinones. magnified image
Topics & Concepts
Enantiopure drugChemistryRegioselectivityStereoselectivityCombinatorial chemistryBiocatalysisOrganic chemistryEnantioselective synthesisCatalysisReaction mechanismSynthesis and Catalytic ReactionsAsymmetric Hydrogenation and CatalysisEnzyme Catalysis and Immobilization