Ruthenium-Catalyzed <i>E</i>-Selective Alkyne Semihydrogenation with Alcohols as Hydrogen Donors
Andreas Ekebergh, Romain Begon, Nina Kann
Abstract
-alkenes has been achieved using alcohols as the hydrogen source. The method employs a simple ruthenium catalyst, does not require external ligands, and affords the desired products in > 99% NMR yield in most cases (up to 93% isolated yield). Best results were obtained using benzyl alcohol as the hydrogen donor, although biorenewable alcohols such as furfuryl alcohol could also be applied. In addition, tandem semihydrogenation-alkylation reactions were demonstrated, with potential applications in the synthesis of resveratrol derivatives.
Topics & Concepts
RutheniumChemistryCatalysisAlkyneYield (engineering)AlkylationAlcoholCombinatorial chemistryHydrogenOrganic chemistryMaterials scienceMetallurgyAsymmetric Hydrogenation and CatalysisCarbon dioxide utilization in catalysisCatalysis and Hydrodesulfurization Studies