Cellular context of IL-33 expression dictates impact on anti-helminth immunity
Li‐Yin Hung, Yukinori Tanaka, Karl Herbine, Christopher Pastore, Brenal Singh, Annabel A. Ferguson, Nisha Vora, Bonnie Douglas, Kelly Zullo, Edward M. Behrens, Tiffany Tan, Michael A. Kohanski, Paul Bryce, Cailu Lin, Taku Kambayashi, Danielle R. Reed, Breann L. Brown, Noam A. Cohen, De’Broski R. Herbert
Abstract
subset. We propose that perforin-2 can provide a plasma membrane conduit in DCs that promotes the export of IL-33, contributing to mucosal immunoregulation under steady-state and infectious conditions.
Topics & Concepts
PerforinContext (archaeology)BiologyImmunityCell biologyImmunologyImmune systemCD8PaleontologyIL-33, ST2, and ILC PathwaysEosinophilic Esophagitis