Human Anti-neuraminidase Antibodies Reduce Airborne Transmission of Clinical Influenza Virus Isolates in the Guinea Pig Model
Jessica Tan, George O’Dell, Matthew M. Hernandez, Emilia Mia Sordillo, Zenab Kahn, Divya Kriti, Harm van Bakel, Ali H. Ellebedy, Patrick C. Wilson, Viviana Simon, Florian Krammer, Meagan McMahon
Abstract
The burden of influenza remains substantial despite unremitting efforts to reduce the magnitude of seasonal influenza epidemics and prepare for pandemics. Although vaccination remains the mainstay of these efforts, current vaccines are designed to stimulate an immune response against the viral hemagglutinin.
Topics & Concepts
BiologyVirologyNeuraminidasePandemicHemagglutinin (influenza)VaccinationTransmission (telecommunications)VirusHuman influenzaHerd immunityInfluenza A virusAntibodyImmune systemOriginal antigenic sinImmunologyCoronavirus disease 2019 (COVID-19)Antigenic driftInfectious disease (medical specialty)DiseaseMedicinePathologyElectrical engineeringEngineeringInfluenza Virus Research StudiesRespiratory viral infections researchViral gastroenteritis research and epidemiology