Biopolymeric and lipid-based nanotechnological strategies for the design and development of novel mosquito repellent systems: recent advances
Chinekwu Sherridan Nwagwu, Adaeze Linda Onugwu, Adaeze Echezona, Samuel Wisdom Uzondu, Chinazom Precious Agbo, Franklin Chimaobi Kenechukwu, John Dike Ogbonna, Lydia Ugorji, Lotanna Gilbert Nwobi, Obichukwu Chisom Nwobi, Oluchi Mmuotoo, Ezinwanne Nneoma Ezeibe, Brigitta Loretz, Clemence Tarirai, Kingsley C. Mbara, N. B. Agumah, Petra O. Nnamani, Kenneth C. Ofokansi, Claus-Micheal Lehr, Anthony A. Attama
Abstract
, solid lipid micro/nanoparticles, micro/nanoemulsions, or liposomes) possess desirable properties such as high biocompatibility, versatility, and controlled/sustained drug delivery, and thus are very important in tackling the clinical challenges of conventional repellent systems. Their capability for controlled/sustained drug release has improved patient compliance as it removes the need for consistent reapplication of repellents. They can also be engineered to reduce repellents' skin permeation, consequently improving their safety. However, despite the benefits that these systems offer very few of them have been successfully translated to the global market for commercial use, a vital challenge that previous reports have not thoroughly examined. The issue of limited clinical translation of novel repellent systems is a vital aspect to consider, as the ultimate goal is to move these systems from bench to bedside. As such, this study seeks to highlight the recent advances in the use of biopolymeric and lipid-based systems for the development of novel mosquito-repellent systems and also analyze the challenges that have limited the clinical translation of these systems while proposing possible strategies to overcome these challenges.