Targeting SARS-CoV-2 spike protein by stapled hACE2 peptides
Marijn N. Maas, Jordi C. J. Hintzen, Philipp M. G. Löffler, Jasmin Mecinović
Abstract
Stapled hACE2 peptides inhibit the formation of the SARS-CoV-2-hACE2 complex, providing the basis for the development of anti-COVID-19 therapeutics.
Topics & Concepts
Spike ProteinSpike (software development)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakVirologyComputational biologyChemistryBiologyMedicineComputer scienceInternal medicineInfectious disease (medical specialty)OutbreakSoftware engineeringDiseaseSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studiesvaccines and immunoinformatics approaches